The Pharmacogenetics of the Antimalarial Amodiaquine
نویسنده
چکیده
José Pedro Gil1,2,3 1Department of Physiology and Pharmacology, Drug Resistance Unit, Division of Pharmacogenetics, Karolinska Institutet, Stockholm, 2Department of Biomedical Sciences, University of Algarve IBB-Institute for Biotechnology and Bioengineering, The Centre for Molecular and Structural Biomedicine, Gambelas, 3Department of Biological Sciences, The Harpur College of Arts and Sciences, Binghamton University, Binghamton, the New York State University, NY, 1Sweden 2Portugal 3USA
منابع مشابه
Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...
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Background and Objective: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern in the developing countries. This problem has prompted investigators for finding alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is an antimalarial which is effective against many chloroquine-resistant strains of P. falciparum. H...
متن کاملSynthesis and study of effects of new 4-chloro – amodiaquine analogues against two resistant and sensitive forms to chloroquine Plasmodium Falciparum, in vitro
Background: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern of the developing countries.This resistance has prompted a re-examination of the pharmacology of alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is a 4-aminoquinoline antimalarial which is effective against many chloroquine-resistant strains o...
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Introduction: Amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated in detail. This article presents and reviews a case of amodiaquine-associated asthenia. A literature search for the characteri...
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Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of a reactive metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules, leading to hepatotoxicity and agranulocytosis. Interchange of the 3 ́ hydroxyl and the 4 ́ Mannich side-chain function of amodiaq...
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